UniPB-80L is a boronic acid affinity resin in which boronic acid forms a coordination compound with cis-diol for separation and purification. Under alkaline conditions, boronic acid functional group interacts with the cis isomer of a 1,2-diol forming a stable five-membered cyclic adduct of cis-diol molecules and boronic acid on the stationary phase. Under acidic conditions, the adduct ring opens releasing the target molecules. UniPB-80L is based on matrix of monodisperse polymethacrylate resin, which enables high flow rate operation. UniPB-80L has been employed in the separation of biomolecules such as glycoproteins, nucleosides, nucleotides, etc.. A typical application of UniPB-80L is to scavenge glycoprotein impurities of recombinant proteins through a flow-through mode.